Comparison Item | Conventional PRP | ExoSmart™ Autologous Blood-Derived Exosomes |
|---|---|---|
| Key Active Components | Platelets + Plasma Proteins | Highly Concentrated Autologous Blood-Derived Exosomes + Growth Factors |
| Extraction Technology | Simple Centrifugation | 15 kDa Ultrafiltration |
| Exosome Concentration | Low (Non-selective) | Approx. 30 Trillion per mL (100× or More ↑) |
| Removal of Unnecessary Components | Limited (Residual Salts/Moisture) | Effectively Removes Salts and Moisture Through Precision Filtration |
| Immunogenicity | Low | Extremely Low (Pure Autologous EVs) |
| Cellular Regeneration Mechanism | Growth Factor Release-Focused | EV-Based Paracrine Signaling + Growth Factors |
| International Validation Standards | Varies by Device | MISEV 2023 EV Validation + CE MDR Certification |
| Stability & Reproducibility | Operator/Device Variability Exists | High Reproducibility Through a Standardized Protocol |
Autologous Exosome Therapy
ExoSmart™ Regenerative Solution
Regenerate your skin from the source with high-purity autologous exosomes extracted from your own blood
Extracting approximately 30 trillion autologous exosomes per 1 mL with the 15 kDa ultrafiltration technology of ExoSmart™, an MFDS-approved Class III medical device · Skin regeneration at the cellular level
About Exosome
Exosomes, the Key Messengers of Cellular Regeneration
Exosomes are 50–200 nm nanoscale extracellular vesicles secreted by cells. They act as biological messengers, delivering key regenerative components such as growth factors, proteins, and RNA between cells.
The Skin Regeneration Mechanism of Exosomes
Exosomes are enclosed by a lipid bilayer similar to the cell membrane, allowing them to move freely through various tissues in the body. The growth factors, cytokines, mRNA, and other signals they carry deliver regenerative and immune-modulating messages to recipient cells, promoting collagen synthesis and tissue repair.
The Science of Light and Shadow
The impression of a face is determined not by the absolute amount of volume, but by the contrast between the surfaces that catch light and those that create shadow. The Other designs this balance of light and shadow.
Promotes Collagen and Elastin Synthesis
Activates the migration and proliferation of dermal fibroblasts, increasing the synthesis of type I and III collagen and elastin.
Anti-inflammatory and Immune-Modulating Effects
Suppresses inflammatory cytokines and amplifies anti-inflammatory signals, shifting damaged tissue environments toward regeneration.
Why Autologous
Why Autologous Blood-Derived Exosomes?
These are the decisive advantages of autologous exosomes extracted directly from your own blood compared with allogeneic exosomes.
Immunological Safety
Because the components are derived from your own cells, the risk of immune rejection is fundamentally minimized. With no chemical additives or foreign proteins, the risk of allergic or inflammatory reactions is extremely low.
Personalized Biological Signals
Autologous exosomes contain the patient’s own biological information, allowing them to interact most efficiently with their own cells. Unlike standardized allogeneic products, they offer a higher response rate in recipient cells.
Same-Day Treatment Without Cell Culture
Extraction and treatment can be performed on the same day after blood collection. Because there is no cell culture process, there is no risk of cell alteration, contamination, or mutation during culture, and the treatment is highly time-efficient.
ExoSmart™ Technology
ExoSmart™ — High-Precision Ultrafiltration
Autologous Exosome Extraction System
This is a high-concentration autologous exosome medical device developed by Italy’s Medica S.p.A. based on hemodialysis filter technology. It applies a 15 kDa ultrafiltration principle using a hollow fiber membrane filter.
01
Blood Collection
A small amount of autologous blood is collected
02
Centrifugation
Plasma and red blood cells are physically separated
03
Ultrafiltration
Selective concentration of exosomes and growth factors only through a 15 kDa filter
04
High-Concentration Recovery
Secures approximately 30 trillion exosomes per 1 mL
05
Treatment Application
Customized injection into the dermal layer
PLUS & MINUS SOLUTION
Officially Certified and Verified in Korea and Abroad
MFDS Approval
Class III Medical Device
(Blood Processing Device)
Approval No. 25-111
CE MDR Certification
EU Medical Device Regulation
(Regulation 2017/745)
Conformity Certification
ISO 13485
International Certification for
Medical Device Quality Management
System (2024)
MISEV 2023
EV Verification Completed
According to the Guidelines of the
International Society for Extracellular Vesicles (ISEV)
Certifications & Standards
A Two-Way Contouring Solution: Reduce and Restore
A natural contour cannot be created with a one-directional treatment alone.
The Other balances the entire face with a two-way solution: reducing what is unnecessary and restoring what has collapsed.
~30 Trillion
particles / mL
Exosome Concentration Yield
100×
vs Conventional Solutions
Exosome Concentration Comparison
15kDa
MWCO cutoff
Ultrafiltration Precision
6 Weeks
post-treatment
Observed Skin Improvement Point
PubMed
Proffer SL et al. “Efficacy and Tolerability of Topical Platelet Exosomes for Skin Rejuvenation: Six-Week Results.” Aesthetic Surgery Journal, 2022. — Significant improvement in erythema, wrinkles, melanin reduction, and skin health scores
PMC
Wyles SP et al. “Topical Platelet Exosomes Reduce Senescence Signaling in Human Skin.” PMC, 2024. — Confirmed reduction in p16 senescent cells and increased expression of collagen and elastic fiber genes
MDPI
“A Purified Platelet-Derived Exosome Product for Chronic Wound Healing.” Pharmaceutics, 2026. — Tissue regeneration mediated by key growth factors such as PDGF, VEGF, and TGF-β
J Cosmet Dermatol
Gupta AK et al. “Therapeutic Potential of Extracellular Vesicles Derived From Platelet-Rich Plasma.” J Cosmet Dermatol, 2024. — Review of PRP-derived exosomes and their effects on collagen synthesis and hair growth promotion
Mayo Clinic
Mayo Clinic research team: Confirmed skin regeneration and restoration of hair follicles and sweat glands in chronic ischemic wounds using platelet-derived exosomes (preclinical)
Comparison
Comparison with Conventional Autologous Blood Treatments
RECOMMENDED
Recommended For
Autologous exosome regenerative therapy addresses a wide range of skin concerns at the cellular level.
Fine Lines and Skin Aging
Restores dermal density by promoting collagen and elastin synthesis, helping improve wrinkles naturally
Loss of Elasticity and Sagging
Restores structural firmness by strengthening the skin basement membrane and remodeling the ECM (extracellular matrix)
Dryness and Rough Skin Texture
Restores a smooth, hydrated texture by normalizing skin barrier function and improving moisture retention
Redness and Sensitive Skin
Relieves chronic inflammation and strengthens skin immunity through anti-inflammatory cytokine-mediated immune modulation
Post-Treatment Recovery Support
Accelerates recovery of damaged tissue after laser, peeling, and other treatments using autologous growth factors
Pores and Scars
Improves enlarged pores and atrophic scars through ECM reconstruction and dermal regeneration
Pigmentation and Uneven Tone
Restores a clear, even skin tone by regulating melanin production and normalizing cell turnover
Overall Skin Vitality
Helps maintain the skin’s biological youth by suppressing cellular senescence and reducing telomere damage
Procedure
Treatment Process
Step 01
Precision Skin Diagnosis
Analysis of each patient’s skin condition and creation of a treatment plan
[Approx. 15 min]
Step 02
Small-Volume Blood Collection
Small-volume autologous blood collection (similar to a standard blood test)
[Approx. 5 min]
Step 03
ExoSmart™ Processing
Centrifugation → Ultrafiltration → High-concentration exosome extraction
[Approx. 30 min]
Step 04
Customized Treatment
Dermal injection, MTS, or booster-style application
[Approx. 30 min]
Step 05
Finishing Care
Regeneration-promoting LED and moisturizing care
[Approx. 15 min]
Start skin regeneration with your own exosomes
The expert medical team at The Other Dermatology precisely analyzes each individual’s skin condition and designs the optimal autologous exosome regeneration protocol.
