Comparison Item | Conventional PRP | NOVASTEM Autologous Blood Concentrate |
|---|---|---|
| Key Active Components | Platelets + Plasma Proteins | Platelets + immune cells + growth factors + extracellular vesicles |
| Concentration Method | Centrifugation-focused | Centrifugation + dedicated concentration kit |
| Concentration Target | Platelet-focused | The active cells of the PBMC layer overall |
| Cell Culture | None | None (minimal manipulation · same-day use) |
| Immunogenicity | Low | Low (autologous cells) |
| Cellular Regeneration Mechanism | Growth Factor Release-Focused | Cell-to-cell signalling · microenvironment conditioning |
| Route of Application | Mainly local injection | Skin · scalp · intravenous |
| Combined Treatments | Limited | Combines with Ulthera, Thermage, Rejuran, Juvelook and more |
Autologous Cell Regeneration
Autologous Cell Regeneration (NOVASTEM)
Build the conditions your skin can respond in, with high-purity autologous cells concentrated from your own blood
Not platelets alone, but immune cells, growth factors and extracellular vesicles — the active components of your own blood, concentrated at high purity · Same-day treatment with no cell culture
About NOVASTEM
Active Blood Cells, the Starting Point of a Regenerative Environment
Beyond platelets, blood contains lymphocytes, monocytes, NK cells, T cells, B cells and dendritic cells, together with signalling molecules. NOVASTEM is a system focused on concentrating these components at high purity.
The Skin Regeneration Mechanism of NOVASTEM
Skin recovery is not determined by any single component. A response emerges when inflammation control, cell-to-cell signalling, the microenvironment, vascular response and cell migration work together. NOVASTEM is directed at creating a biological environment in which tissue can respond.
Recovery Signalling (SDF-1α)
SDF-1α (CXCL12) is known as a signalling axis that helps progenitor and mesenchymal cells migrate toward sites in need of repair.
Promotes Collagen and Elastin Synthesis
Activates the migration and proliferation of dermal fibroblasts, increasing the synthesis of type I and III collagen and elastin.
Anti-inflammatory and Immune-Modulating Effects
Suppresses inflammatory cytokines and amplifies anti-inflammatory signals, shifting damaged tissue environments toward regeneration.
Why Autologous
Why Autologous?
These are the differences of a preparation concentrated directly from your own blood, compared with one manufactured externally.
Immunological Safety
Because the components are derived from your own cells, there is no concern of immune rejection. With no chemical additives or foreign proteins added, the risk of allergic or inflammatory reactions is low.
Your Own Biological Information
An autologous preparation carries the patient’s own biological information, so it acts by interacting with their own cells. This is a different approach from a standardized external product.
Same-Day Treatment Without Cell Culture
Concentration and treatment can be performed on the same day after blood collection. Because cells are not cultured outside the body, there is no risk of alteration or contamination during culture, and they are used fresh.
NOVASTEM Technology
NOVASTEM — High-Purity Cell Concentration
Autologous Blood Cell Concentration System
Collected autologous blood is centrifuged to separate the PBMC (peripheral blood mononuclear cell) layer, where the active cells are concentrated, and is then concentrated at high purity using a dedicated kit. It is a minimal-manipulation process with no cell culture.
01
Blood Collection
Autologous blood is collected according to the treatment goal
02
Centrifugation
Blood is physically separated into layers
03
Cell Separation
Active cells and signalling molecules are selected from the PBMC layer
04
High-Concentration Recovery
The high-purity concentrate is recovered with a dedicated kit
05
Treatment Application
Injected into skin, scalp or vein according to the goal
PRINCIPLES
The Four Principles of NOVASTEM Treatment
Autologous Blood
Your own blood only
(no allogeneic components)
No concern of immune rejection
Minimal Manipulation
No cell culture —
(separation and concentration only)
Used the same day
High-Purity Concentration
Active cells and signalling
molecules from the PBMC
layer are selected
Route by Purpose
Skin, scalp or vein
chosen by condition
and treatment goal
EVIDENCE
Clinical Observations Provided by the Manufacturer
The figures below are based on small-scale clinical observation data provided by the NOVASTEM manufacturer.
Results vary between individuals and are not guaranteed to be the same for everyone.
10/11
subjects
Telomere length increase observed
4 Weeks
post-IV
Serum serotonin elevation sustained
120–240 mL
blood drawn
Per-session volume (scalp protocol)
7–10 Days
post-injection
Skin response window
J Cosmet Med
Kim KB, Kim DK. “Therapeutic efficacy of TriCell CD34+ cell-containing, platelet-rich plasma in alopecia patients.” J Cosmet Med, 2020;4(1):36-40. — Improved hair thickness and density after three sessions at 4-week intervals (n=10)
Mechanism
The SDF-1α (CXCL12) axis — known to be involved in the migration and homing of progenitor and mesenchymal cells and in shaping the tissue microenvironment after injury.
Manufacturer data
Telomere length analysis — an increase in length after treatment was observed in 10 of 11 subjects. (small-scale observational data)
Manufacturer data
Serum serotonin analysis — elevated levels tended to be sustained through 4 weeks after intravenous administration. (small-scale observational data)
Disclosure
This is a non-reimbursed anti-aging and cosmetic procedure, not a treatment for disease. The onset and duration of any effect vary between individuals.
Comparison
Comparison with Conventional PRP
RECOMMENDED
Recommended For
NOVASTEM is directed at creating an environment in which skin can respond to recovery signals.
Fine Lines and Skin Aging
Restores dermal density by promoting collagen and elastin synthesis, helping improve wrinkles naturally
Loss of Elasticity and Sagging
Restores structural firmness by strengthening the skin basement membrane and remodeling the ECM (extracellular matrix)
Dryness and Rough Skin Texture
Restores a smooth, hydrated texture by normalizing skin barrier function and improving moisture retention
Chronic Inflammatory Redness
Helps ease recurring redness and a chronically inflamed environment through anti-inflammatory signalling
Post-Treatment Recovery Support
Accelerates recovery of damaged tissue after laser, peeling, and other treatments using autologous growth factors
Those Who React to Foreign Materials
Because only your own blood is used, those who have reacted to external preparations may consider it after consultation
Sensitive Skin That Responds Slowly
For skin that has responded weakly to repeated treatments, it helps prepare the groundwork so other treatments can respond better
Recovery Before an Occasion
Worth considering when you need skin and overall condition to recover quickly ahead of an important occasion
Procedure
Treatment Process
Step 01
Precision Skin Diagnosis
Analysis of each patient’s skin condition and creation of a treatment plan
[Approx. 15 min]
Step 02
Autologous Blood Collection
Autologous blood is collected according to the treatment goal
[Approx. 5 min]
Step 03
NOVASTEM Processing
Centrifugation → PBMC layer separation → high-purity cell concentration
[Approx. 30 min]
Step 04
Customized Treatment
Injected into skin, scalp or vein according to the goal
[Approx. 30 min]
Step 05
Finishing Care
Regeneration-promoting LED and moisturizing care
[Approx. 15 min]
Prepare your skin’s groundwork with your own blood
The expert medical team at The Other Dermatology precisely analyzes each individual’s skin condition and designs a NOVASTEM autologous blood regeneration protocol together with you.